Hwangseo Park Selected Research

cdc25 Phosphatases

8/2009	Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors.
9/2008	Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening.
9/2008	Toward the virtual screening of Cdc25A phosphatase inhibitors with the homology modeled protein structure.
8/2008	Nanosecond molecular dynamics simulations of Cdc25B and its complex with a 1,4-naphthoquinone inhibitor: implications for rational inhibitor design.

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Hwangseo Park Research Topics

Disease

29	Neoplasms (Cancer) 03/2021 - 06/2004
3	Dehydration (Water Stress) 03/2021 - 01/2016
3	Obesity 08/2011 - 08/2009
2	Carcinogenesis 01/2019 - 01/2017
2	Stroke (Strokes) 01/2019 - 07/2014
2	Inflammation (Inflammations) 02/2016 - 01/2005
2	Immune System Diseases (Immune Disorders) 09/2015 - 03/2012
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 06/2013 - 08/2012
2	Sarcoma (Soft Tissue Sarcoma) 01/2012 - 10/2011
2	Weight Gain 11/2010 - 11/2009
1	Respiratory Syncytial Virus Infections 12/2021
1	Human Influenza (Influenza) 09/2021
1	Leukemia 03/2021
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2020
1	Infections 01/2020
1	Brain Injuries (Brain Injury) 01/2019
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2019
1	Brain Infarction 01/2019
1	Osteoporosis 10/2018
1	Huntington Disease (Huntington's Disease) 08/2017
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017
1	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2017
1	Neuroinflammatory Diseases 01/2015
1	Atherosclerosis 12/2014
1	Vascular Diseases (Vascular Disease) 02/2013
1	Pain (Aches) 11/2011
1	Asthma (Bronchial Asthma) 11/2010
1	Anemia 11/2009
1	Type 2 Diabetes Mellitus (MODY) 08/2009
1	Alzheimer Disease (Alzheimer's Disease) 12/2003

Drug/Important Bio-Agent (IBA)

12	Pharmaceutical PreparationsIBA 09/2021 - 08/2008
6	Proteins (Proteins, Gene)FDA Link 03/2021 - 12/2014
6	Phosphotransferases (Kinase)IBA 03/2021 - 11/2011
5	Phosphoric Monoester Hydrolases (Phosphatases)IBA 08/2017 - 04/2008
4	cdc25 PhosphatasesIBA 08/2009 - 08/2008
3	Adenosine Triphosphate (ATP)IBA 01/2018 - 11/2007
3	Protein Tyrosine PhosphatasesIBA 09/2012 - 08/2011
2	Antiviral Agents (Antivirals)IBA 12/2021 - 01/2020
2	LigandsIBA 03/2021 - 01/2012
2	p38 Mitogen-Activated Protein KinasesIBA 09/2015 - 03/2012
2	Proto-Oncogene Proteins B-rafIBA 01/2012 - 10/2011
2	Nonesterified Fatty Acids (NEFA)IBA 11/2010 - 11/2009
2	CholesterolIBA 11/2010 - 11/2009
1	Palivizumab FDA Link 12/2021
1	Proto-Oncogene Proteins c-pim-1 (Proto Oncogene Proteins c pim 1)IBA 03/2021
1	ErbB Receptors (EGF Receptor)IBA 12/2020
1	ZincIBA 01/2019
1	Oncogene Proteins (Oncogene Protein)IBA 01/2019
1	Retinoblastoma ProteinIBA 01/2019
1	AMP-Activated Protein KinasesIBA 01/2019
1	Class 4 Receptor-Like Protein Tyrosine PhosphatasesIBA 10/2018
1	Polytetrafluoroethylene (Teflon)FDA Link 01/2018
1	Aurora Kinase AIBA 01/2018
1	Streptozocin (Streptozotocin)FDA Link 01/2017
1	Riluzole FDA LinkGeneric 01/2017
1	Protein Kinase CIBA 01/2017
1	SilverIBA 01/2017
1	STK899704IBA 01/2017
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2017
1	Biological ProductsIBA 01/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2017
1	Antineoplastic Agents (Antineoplastics)IBA 02/2016
1	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA 02/2016
1	ResveratrolIBA 02/2016
1	PolyphenolsIBA 02/2016
1	Anaplastic Lymphoma KinaseIBA 01/2016
1	Amino Acids FDA Link 01/2016
1	Dual-Specificity PhosphatasesIBA 12/2014
1	Protein Kinases (Protein Kinase)IBA 07/2014
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 06/2013
1	bcr-abl Fusion ProteinsIBA 08/2012
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2012
1	NocodazoleIBA 01/2012
1	TropomyosinIBA 11/2011
1	Mitogen-Activated Protein KinasesIBA 05/2011
1	Phosphatidylinositols (Phosphatidylinositol)IBA 04/2011
1	Hypoglycemic Agents (Hypoglycemics)IBA 11/2010
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2010
1	2,4-thiazolidinedione (thiazolidinedione)IBA 11/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2010
1	Histone Deacetylases (Histone Deacetylase)IBA 04/2010
1	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 08/2009
1	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA 10/2008
1	Adenosine Triphosphatases (ATPase)IBA 11/2007
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2005
1	Cyclin-Dependent Kinase 4IBA 12/2004
1	Histone Deacetylase InhibitorsIBA 06/2004
1	Aspartic Acid ProteasesIBA 12/2003
1	Amyloid beta-PeptidesIBA 12/2003
1	Peptides (Polypeptides)IBA 12/2003
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 12/2003

Therapy/Procedure

20	Therapeutics 01/2020 - 06/2004
1	Injections 01/2019
1	Glycemic Control 08/2011